The 2^nd International Conference on Orthogonal Polynomials, Special Functions and Computer Algebra: Applications in Engineering will take place in Jaipur, India from October 15th -16th 2022 . It is jointly organized by the Anand International College of Engineering, Anand College, India and International Telematic University (UNINETTUNO), Italy. Conference provide a forum for mathematicians, physicists, and computational scientists to communicate recent research results in the areas of orthogonal polynomials, special functions and Computer Algebra with their Applications in Engineering . These play an essential role in analytical and computational investigations in applied mathematics as well as in engineering. This Conference promotes basic research in orthogonal polynomials and special functions, as well as applications of this subject in other parts of mathematics, and in science and industry. It encourages and supports the exchange of information, ideas, and techniques between workers in this field and other mathematicians and scientists.